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The family of MyDoom e-mail worms remains an active threat because of compromised computer systems and unprotected personal computers even though the virus was programmed to shut down last month. As a result of the prevalent infections, the MyDoom creators still can mobilize a vast network of computers at any time. Marching orders sent to infected machines can enable them to carry out misdeeds ranging from clogging Internet traffic to wreaking large-scale financial chaos on banks and corporations, according to virus experts.
I believe that to reduce the impact of viruses like MyDoom etc a technology solution is required to eliminate infection through social engineering. A solution which requires a password to launch any new executable (which viruses typically are), would completely stop the infection if the user is unaware of the password, and would inform any administrator user that this is a new executable and highly suspect.